Newest Medication For Depression
Q: Paxil (paroxetine hydrochloride), a new antidepressant medication,was
introduced into the United States in early 1993. It is a member of the
SSRI (selective serotonin reuptake inhibitor) family(along with Zoloft
and Prozac). These new medications are effective in alleviating the
symptoms of major depression without causing some of the harmful
side effects caused by the oldertricyclic antidepressants (TCAs).
A:What does Paxil treat?
Depression is a biologically based disorder, although social and
genetic factors may contribute to the illness. Depression is
associated with a decreased number of neurotransmitters in the
brain (particularly serotonin and norepinephrine). These chemical
messengers help regulate several functions and thoughts, including
mood. Paxil blocks the reabsorption of serotonin and normalizes the
brain's chemical supply.
What are the advantages of Paxil over other antidepressants?
Paxil is as effective in relieving depression as TCAs such as
imipramine. However, Paxil causes fewer adverse cardiovascular
and anticholinergic effects (dry mouth, constipation, blurred vision,
urinary retention) than the older TCAs. It does not usually cause
drowsiness, low blood pressure, or weight changes. Paxil has no
active metabolites and leaves one's system 24 hours after it enters.
SmithKline Beecham Pharmaceuticals, which makes Paxil, states
that Paxil is the most selective of the SSRI antidepressants. This
selectivity causes serotonin levels in the brain to normalize quickly,
relieving depression with relatively few side effects.
Who can benefit from taking Paxil?
Paxil is equally effective in elderly depressed patients as it is in
younger. Elderly people may turn to Paxil for relief because it does
not cause significant changes in blood pressure, unlike Effexor
and some other antidepressants.
Paxil is effective in the treatment of anxiety which accompanies
depression in some people. Those experiencing lethargy at the
beginning of treatment can also take Paxil with positive results
because Paxil does not impair psychomotor function.
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