Zoloft Side Effects

Q: I started taking Zoloft last friday(25mg/day) and I've already started feeling more relaxed, but I'm getting some unpleasant side effects. I'm having problems concentrating & sleeping and my head feels heavy and as if an uncomfortable amount of presure was being applied to it. I've lowered my dosage to 5mg a day and the problems concentrating has mostly gone and the other problems aren't as bad but are still there. Can I expect these side effects to go away with time? If so, how long? If they don't go away, am I likely to have better luck with a different SSRI or to have the same problems?

A:I have tried many SSRI's for my anxiety, and have not found one I am completely happy with yet. I have consistently been on clonazepam, though, and it works wonderfully. My doctor says the SSRI's have different side effects for everyone...your individual brain's biochemistry will determine how well each one works for you and how many side effects you encounter. I am currently on Prozac, but it, like all the SSRI's I have tried, have sexual side effects for me. But certainly some have been much better than others. Sexual effects aside, Zoloft was by far the worst for me (I couldn't stop tensing up, grinding my teeth, even on 1/2 of the lowest dosage) while Paxil had the best anxiolytic effects. So my opinion would be to give it a shot. If the side effects remain, keep trying the other ones until you find one that works for you. All anti-depressants can cause a increase in anxiety while weaning on them. It really is a normal, and quite common to experience some side-effects while weaning on Ad`s. You could switch from Zoloft to Paxil, and find you have the same side-effects, or it is much worse on Paxil. No one can tell you how you will react on any medication, it is a matter of you getting on the med and seeing for yourself. Please don`t get discouraged, it does get better. Let me suggest instead of taking 25mgs of Zoloft, go to 12.5mgs, and do all your increases in 12.5mg increments, and stay at each increase for one week. You may find this helps lessen those side-effects you were feeling. We have a poster here that has had great success weaning on Zoloft in this manner.

It can`t hurt to try. Unfortunately, sometimes to get better, we have to tolerate side-effects of certain meds, that will eventually help us. I am not sure about the safety with taking Melatonin and Zoloft, so I can`t comment. If you are having problems with sleep, don`t take the Zoloft in the PM, take it in the AM. You could ask your doctor for a prescription for something to aid your sleep, Ambien from what I hear is good. Another option, and of course ask your doctor, is to take Benadryl, also known as "Diphenhydramine", it is a anti-histamine, but is quite a effective sleep aid. And is okay for long term use. Take care and hang in there, it will get better :-)