Symptoms Of Depression Are

Q: I recently started taking Lexapro, serotonin based pill for depression. I wonder why most medication for depression seem to focus on serotonin uptake inhibitors rather than adding dopamine?

A:I can't answer your question, but its worth noting that the effectiveness of SSRI's (and SNRI's as well) for treating a variety of conditions has been established largely through clinical trial-and-error without a complete understanding of exactly how or why they work -- at least that's true of those which I am familiar with, which does not include escitalopram. It's possible that drugs which target dopamine have actually been tried but weren't as effective in clinical trials, or had nastier side-effects. I can handle psychotherapy, and I believe it does some good. I have a therapist I can trust, I can tell him everything. But psychopharmaca I do not trust. All the popular antidepressants do cause sexual dysfunction in me (like they do in many others). It's called impotence to be perfectly clear, sorry if that's too much information for you. Just thought that anyone who is confronted with these substances should know. If you do get used to these drugs it's going to be a bitch to get *unused* to them eventually, as well. Do not go "cold turkey" on them! I was on another SSRI (Effexor) for several years, and stopped about 6 months ago. I plan to go back on it, even with the laundry list of side effects. The symptoms of clinical depression are a bitch, even when you know how to recognize them. I am impotent without the drugs, radiation therapy for prostate cancer.

At 72 long term problems seem the least of my concerns. I seem to be more level in my emotional response to stress. That is helpful, but I nap often and have little interest or curiosity. I have 2 goals: ability to take care of myself, living independent (this includes getting some more energy); develop some interests to occupy the day. I am working with a PA who is working with my doctor, not off on my own. I plan to ask about dopamine, but that is a week and a half away. I have 2 books that tout the related symptoms for which dopamine is associated, so I got curious. This group often has valuable experiences and insights, so here I am, hat in hand.